Urolithin powder is not present in food; however, polyphenols that are precursors to urolithins are. Polyphenols are plentiful in a wide variety of fruits and vegetables. Some polyphenols are immediately absorbed by the small intestine after consumption, whereas digestive bacteria metabolize others into other chemicals, some of which are helpful. Certain gut bacteria, for example, convert ellagic acid and ellagitannins into urolithins, which may benefit human health.

What is the purpose of urolithin A?

Because urolithin A is found in various tissues, it has been postulated that it affects many organ systems in worms, cells, mice, and humans. There is substantial evidence from cell, animal, and human studies that urolithin A enhances mitophagy. Mitophagy removes damaged mitochondria from the cell, therefore supporting the formation and maintenance of healthy mitochondria.

Sources of nutrition

So far, research has revealed that ellagic acid and ellagitannins may be found in pomegranate, strawberries, blackberries, Camu-camu, walnuts, chestnuts, pistachios, pecans, brewed tea, and oaken barrel-aged wines and spirits.

Possibility of improving mitophagy

According to a 2016 study, urolithin A enhanced muscular performance in elderly mice and increased worm longevity. Because of these encouraging results, the same study group is now conducting human research investigations. More research on additional urolithins is needed to discover whether they are advantageous for persons who do not consume enough ellagic acid and ellagitannins. Concerns have also been expressed about inadequate dietary production of urolithin A, which is influenced by health conditions, intestinal health, and age.

When compared to supplements, food availability is superior

Urolithin A, available in tablet and powder form, is touted as a supplement that helps reduce age-related cellular decline by boosting mitochondrial health. Amazentis financed the first Phase 1 clinical trial of a pure urolithin A supplement in 100 sedentary older individuals. Before this experiment, a publication was published that demonstrated the safety and effectiveness of urolithin A and a mitochondrial health benefit.

Participants in this newly published clinical trial were divided into three groups based on their circulating urolithin A glucuronide levels. They were requested to refrain from consuming dietary supplements that might interfere with muscle or mitochondrial function.

A pomegranate chemical with anti-aging properties has passed human testing

Urolithin A, a biomolecule present in pomegranates and other fruits, may aid in the prevention of some aging processes. Amazentis, an EPFL spin-off, EPFL and the Swiss Institute of Bioinformatics, released a report in the journal Nature Metabolism summarising the findings of their clinical study.

Methods

The subjects were randomly assigned (1:1) to receive either PJ or a food product containing UA (500 mg). In some groups, the prevalence of UA producers and non-producers was assessed. Diet questionnaires and fecal samples were gathered to investigate differences between UA producers and non-producers, and plasma samples were collected at various time intervals to compare UA and its conjugates levels between treatments.

Conclusion

The initial study revealed that ingesting pure urolithin was beneficial. A supplement was shown to be more effective than pomegranate juice in increasing plasma urolithin A levels. The second study discovered that some eating patterns, such as those resembling the Mediterranean diet vs. a Western diet, increase urine urolithin A levels.

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